What could cause this?

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looks rough. Really need natural light to see better though. Could be deficiency plus nute burn. Hard to say in the purple light.

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This looks like nutrient burn to me. What is the soil, nutes etc.?

Coco coir
Ppm around 650
Week 6/early bloom
Fabric pots, having been getting any drainage tho
Just put a new opticled grow light in
Doing general hydroponics nutrients

I am a bit stumped. It still looks like nute burn to me, but your ppm is not that high. Is this straight coco or is it mixed with something like Fox Farms or the like?
As far as week, I stay on week 4 nutrients until I flip to 12s. (I use GH flora trio also in HP Pro-Mix CC) Week 5/6 is transition and Week 7 for flower until I am ready to close it up. In a word this isn’t a rigid schedule that I follow to the letter, but as my reference.

Here is the feed chart I usually use.
Feedchart

Need to adjust it as required for any deficiency etc. I don’t alway use Flouralicious either. The Epsom’s is 1/4 tsp.